Re-programming the Amygdala Gland in Rats Shows How Fear and Stress Can Be Eliminated

Researchers funded by the National Institute of Mental Health (NIMH) have discovered a high tech way to quell panic in rats. They have detected the brain's equivalent of an "all clear" signal, that, when simulated, turns off fear. The discovery has now lead to non-drug, physiological treatments for runaway fear responses seen in anxiety disorders in humans. This is done by a treatment known as The Linden Method, developed by Charles Linden, a Briton who suffered badly from panic attacks, phobias and stress disorders.

The NIMH experiments were carried out on rats. Rats normally freeze with fear when they hear a tone they have been conditioned to associate with an electric shock. Dr. Gregory Quirk and Mohammed Milad, Ponce School of Medicine, Puerto Rico, have now demonstrated that stimulating a site in the front part of the brain, the prefrontal cortex, extinguishes this fear response by mimicking the brain's own "safety signal." They report on their findings in the November 7, 2002 Nature.
"Repeated exposure to traumatic reminders without any adverse consequences causes fear responses to gradually disappear," explained Quirk. "Such reduction of fear appears to be an active rather than passive process. It doesn't erase the fear association from memory, but generates a new memory for safety."

The researchers recorded electrical activity of neurons in the prefrontal cortex as rats were fear-conditioned — taught to fear a tone by repeatedly pairing it with a shock. Then they abolished this conditioned fear by presenting the tone without the shock; the animals no longer froze when they heard the tone.

Although inactive during both procedures, neurons near the middle of the prefrontal cortex, the infralimbic area, fired conspicuously when the tone was sounded on the following day. This activity proved to be the brain's way of signaling that the tone no longer presaged a shock. The more the cells fired — i.e., the louder this safety signal — the less the rats froze. Animals that showed the most infralimbic activity behaved as if they had never been fear conditioned at all.

The researchers then electrically stimulated the infralimbic area in rats that had been fear conditioned but not extinguished — in effect simulating the safety signal, while pairing it with the tone. Remarkably, the rats showed little freezing. Later, the rats continued to be unafraid of the tone even without the stimulation, suggesting that memory for extinction was strengthened by experimentally mimicking the safety signal.
Since the prefrontal cortex is known to project to the amygdala, a hub of fear memory deep in the brain, the researchers propose that increased activity of infralimbic neurons in the prefrontal cortex strengthens memory of safety by inhibiting the amygdala's memory of fear. They speculate that stimulating parts of the prefrontal cortex in anxiety disorder patients, using an experimental technique called transcranial magnetic stimulation, might help them control fear.

For more information on how The Linden Method can help people suffering from Post Traumatic Stress Disorder, go to www.itsagoodlife.co.uk/worry.html

Help For Post-Traumatic Stress Disorder

Post-Traunatic Stress Disorder, or PTSD for short, is a very real illness that can affect even the strongest, fittest, even the most emotionally well-balanced person.

You will have heard the saying that 'every man has his price', and so it is when a seriously unpleasant event happens to us. we may think that we handled it well at the time, perhaps were even unaffected by it, but later problems start to arise that may not even appear to be connected to that event.

So the symptoms may seemed disconnected to the real cause, which makes a solution harder to find.

Indeed, the sufferer of PTSD may not find much sympathy from friens, family, or the medical profession. Medication may well be offered, but things such as Prozac can have other effects that are detrimental. Some medications can leave the patient feeling suicidal rather than helping with the PTSD. This has actually happened in my own experience.

There is evidence to show that a cause of many fear- and stress-related problems lays in a part of the brain known as the Amygdala. This gland can become re-programmed by a prolonged or severe mental trauma, which results in a bad reaction on an ongoing basis.

But just as this imbalance can be created, so it can be cured. By using a technique called the Linden Method, you can re-train your own brain to cancel out the signals that are causing you this problem.

If you go to www.lindenmethod.com/pages/phoenix you will be able to read more about this method and how it can also benefit many other symptoms that seem to be a result of our ever-more-complicated lives.

The important point to note is that this does not rely on any sort of 'positive-thinking' mumbo-jumbo. Nor are you subjected to hypno-therapy or harmful medications.

www.lindenmethod.com/pages/phoenix